Investigator- Complex In Vitro Models (Langhorne)


: $150,470.00 - $150,470.00 /year *

Employment Type

: Full-Time


: Advertising/Marketing/Public Relations

We are seeking a highly productive and motivated bench scientist with a track record in developing highly sophisticated complex In Vitro Models that require applied bio-engineering and/or developing and incorporating microphysiological systems for drug development. The successful candidate will be responsible for seeking, developing, qualifying translational cellular models for higher throughput and lower throughput high complexity models. The candidate would join the Complex In Vitro Models (CIVM) team within In Vitro In Vivo translation (IVIVT) department in GSKs research organization in Upper Providence. CIVMs mission is to improve predictive and translational value of preclinical models. We strive to improve models for MOA, efficacy, safety and metabolism, aiming to assess these in the same systems whenever possible. The CIVM group closely collaborates with the research units, the medicinal science and technology (MST) organization and other IVIVT groups. The bench scientist will have the opportunity to work in Immunology based diseases and multiple disease areas.

Key Responsibilities:

  • Activities may include any of the following:Develop and apply complex in vitro assays including 3D multi-cellular cultures, Organoids, microphysiological systems, 3D bioprinting and organ-on-a-chip approaches for Innate and Adaptive Immunology, Oncology, neurobiology and/or liver models.Development and application of advanced cellular models incorporating components of the immune system, and will participate primarily in the early profiling of drug candidates across different disease areas.Responsible for designing and conducting in vitro experimental activities addressing molecular and cellular aspects in combination with imaging technologies for drug efficacy and PK/PD models.Test the functional consequences of genetic variants in cell-based model systems using methods that include CRISPR-based gene editing technologies
  • Work in a matrix team environment to ensure optimal delivery of project and department objectives to the highest possible scientific standard
  • Independently execute laboratory experiments, apply advanced data analysis, integration and interpretation with an emphasis on providing appropriate context for data and experiments in order to progress programs and/or develop platforms
  • Play a key role in scientific due diligence and guidance on CIVMs with project teams and other departments
  • Responsible for developing and managing one or more external CIVM collaborations
  • Demonstrate strong scientific leadership as well as excellent written and oral communication
  • Ensure compliance with all GSK R&D data integrity practices, ethics codes, standards and training, and safety training and practice.
  • Why you?

    Basic Qualifications:

    We are looking for professionals with these required skills to achieve our goals:

  • PhD in a related field or MS in a related field with 5 years of experience.
  • Publications in peer reviewed journals
  • Contributions in developing CIVMs for drug discovery projects
  • Demonstrated knowledge of a broad range of cell biology and cellular engineering technologies
  • Preferred Qualifications:

    If you have the following characteristics, it would be a plus:

  • PhD
  • Assay Implementation, development, and automation in a pharmaceutical drug discovery setting
  • Experience in developing and qualifying complex in vitro models that are 3D tumor, vascularized, or epithelial barrier models
  • Why GSK?

    Our values and expectationsare at the heart of everything we do and form an important part of our culture.

    These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:

  • Operating at pace and agile decision-making using evidence and applying judgement to balance pace, rigour and risk.
  • Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution.
  • Continuously looking for opportunities to learn, build skills and share learning.
  • Sustaining energy and well-being.
  • Building strong relationships and collaboration, honest and open conversations.
  • Budgeting and cost-consciousness.
  • If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK HR Service Centre at 1-877-###-#### (US Toll Free) or +1 801 ### #### (outside US).

    GSK is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.

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    * The salary listed in the header is an estimate based on salary data for similar jobs in the same area. Salary or compensation data found in the job description is accurate.

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