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We are seeking a highly-motivated scientist to fill a molecular biology laboratory position in the Protein, Cell, & Structural Sciences Department within the Medicinal Science & Technology division of R&D located in Upper Providence, PA. The primary responsibility of the department is to design, generate and validate biological reagents for discovery activities across all of GSKs therapeutic modalities. The department also provides the structural and mechanistic understanding of drug target, molecular recognition, and mode of action to deliver the best molecule.

The successful candidate will be responsible for theconceptual design andgeneration of protein and cellular reagents for use in GSKs small molecule drug discovery platforms. Automation, data science and in silico protein design skills are all desirable, as GSKs future molecular biology strategy must enable high throughput protein expression platforms. This scientist will have the opportunity to work on targets in multiple therapeutic areas. Title and salary will be commensurate with experience.

Key Responsibilities:

  • Work in a matrix team environment to enable optimal delivery of project and department objectives to the highest possible scientific standard
  • Independently execute laboratory experiments and/or advanced data analysis, integration and interpretation with an emphasis on providing appropriate context for data and experiments in the progress of programs and/or platforms
  • Design and generate protein constructs for expression in bacterial, fungal, insect, mammalian systems, and cell-free systems
  • Work closely to enable external partners to generate biological reagents to support GSK discovery programs.
  • Enable high throughput protein expression platforms by contributing protein design, molecular biology, and bioinformatic skills.
  • Ensure compliance with all GSK R&D data integrity practices, ethics codes, standards and training, and safety training and practice
  • Why you?

    Basic Qualifications:

    We are looking for professionals with these required skills to achieve our goals:

  • Bachelors degree in a life sciences discipline (e.g. molecular biology, cellular biology, immunology) with at least 5+ years of relevant laboratory experience, or a Masters with at least 1+ years of relevant laboratory experience.
  • Preferred Qualifications:

    Qualified candidates should have strong track-record in either one or more of the following disciplines: Molecular Biology, Protein Expression/Purification, Protein Design?:

  • Expertise in protein construct design and generation, including reagents for gene editing and functional genomic campaigns
  • Support reagent production timeline goals of generating fit-for-purpose reagents for assays, ASMS, ELT, x-ray crystallography, cryo-EM, biophysics, and enzymology
  • Practical knowledge of automation in molecular biology/cell biology
  • Protein design and/or bioinformatic experience
  • Practical knowledge of gene synthesis, library construct design, and DNA sequencing
  • Ability to plan and execute multiple tasks concurrently and evaluate multiple scientific strategies in parallel where appropriate
  • Demonstrated strengths in high performance behaviors, such as building relationships, flexible thinking, and enabling/driving change
  • Why GSK?

    Today there are still millions of people without access to basic healthcare, thousands of diseases without adequate treatments and millions more people who suffer from everyday ailments. At GSK we want to change this.

    We want to help people do more, feel better, live longer

    We have three world-leading businesses that research, develop and manufacture innovative pharmaceutical medicines, vaccines and consumer healthcare products.

    Across the US, we employ more than 15,000 people who strive to help others do more, feel better and live longer. This work starts one person, one community, and one story at a time. Find out more about how we are doing more across the US

    As a science-led, global healthcare business with clear values, we offer countless opportunities for people at various stages of their careers. On-the-job learning and rewarding individual contributions are extremely important to us. We believe in creating an inclusive and safe working environment and supporting our employees to help their communities.

    *This is a job description to aide in the job posting, but does not include all job evaluation details.

    If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK HR Service Centre at 1-877-###-#### (US Toll Free) or +1 801 ### #### (outside US).

    GSK is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.

    Important notice to Employment businesses/ Agencies

    GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.

    Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSKs compliance to all federal and state US Transparency requirements. For more information, please visit GSKs Transparency Reporting For the Record site.

    Associated topics: aseptic, aseptic technique, dietary, disease, histotechnologist, immunology, nutrition, physiologist, physiology, vaccine

    * The salary listed in the header is an estimate based on salary data for similar jobs in the same area. Salary or compensation data found in the job description is accurate.

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