Principal Scientist, Automated Chemistry (Langhorne)

Compensation

: $85,425.00 - $144,970.00 /year *

Employment Type

: Full-Time

Industry

: Scientific Research



Job Description


JanssenResearch & Development, L.L.C., a division of Johnson & Johnson'sFamily of Companies is recruiting for a Principal Scientist, Automated Chemistry - Discovery Chemistry, located in SpringHouse, PA.

At theJanssen Pharmaceutical Companies of Johnson & Johnson, what matters most ishelping people live full and healthy lives. We focus on treating, curing andpreventing some of the most devastating and complex diseases of our time. Andwe pursue the most promising science, wherever it might be found.

JanssenResearch & Development, LLC discovers and develops innovative medicalsolutions to address important unmet medical needs in oncology, immunology,neuroscience, infectious diseases and vaccines, and cardiovascular andmetabolic diseases. Please visit information.

We areJanssen. Our mission drives us. Our patients inspire us. We collaborate withthe world for the health of everyone in it.

Thriving on adiverse company culture, celebrating the uniqueness of our employees andcommitted to inclusion. Proud to be an equal opportunity employer.

JanssenResearch & Development, LLC, is seeking an experienced, highly skilled, andmotivated medicinal chemist to work in our laboratories in Spring House, PA,for the position of Principal Scientist, Automated Chemistry - Discovery Chemistry. This position will require the candidate topossess and leverage deep knowledge and capabilities to deliver differentiatedclinical candidates to the Janssen product development pipeline within ourDisease and Pathway Area Stronghold strategy. Using a mix of internal and external resources, the Principal Scientistwill partner with key stakeholders within the therapeutic areas and otherinternal groups, represent medicinal chemistry and lead cross-functionalproject teams, and be co-responsible for building, managing, and deliveringhigh quality clinical molecules into the pipeline. Responsibilities of thePrincipal Scientist will include:

  • Drive and directmedicinal chemistry functions for one or more drug discovery projects, workingin concert with partners in molecular and cellular biology, pharmacology,computational chemistry, ADME, structural biology, chemical development, andother key functions
  • Utilize parallelsynthesis technologies and high throughput chemistry to prepare libraries ofcompounds relevant to ongoing hit-to-lead and lead optimization strategies formultiple programs
  • Analyze screening data,perform literature reviews, design, propose, and execute medicinal chemistryplans, coordinate chemistry and biology data to support compound progressionand patent strategies
  • Supervise and directsynthetic chemistry activities internally and/or at contract researchorganizations (CROs)
  • Participate in portfolioand stage-gate reviews, lead the preparation and presentation of dossiers forclinical candidate nomination and compound advancement
  • Participate in shapingand implementing strategies that support medicinal chemistry growth objectivesat Janssen
  • Serve as a scientificexpert in medicinal chemistry with both internal and external partners andprovide recommendations regarding new targets, new synthetic strategies andemerging external opportunities.
  • Ensure optimalinteraction/communication and provide updates on project status to Discoveryleadership
  • Maintain significantpersonal laboratory presence

  • Qualifications
  • A PhDin synthetic or medicinal chemistry with 7 years of related experience is required
  • Postdoctoral experience is preferred
  • A minimum of 7 years experience inthe biopharmaceutical industry with a proven track record of innovativeprojects and key contributions to clinical candidate selection, preferably asproject leader is required
  • Broad experience and proven accomplishmentsin medicinal chemistry with operational skills for managing discovery programsat the level of a senior chemist/team leader and a proven track record ofdelivering clinical candidates is required
  • Expert knowledge of modern methods ofsynthetic and medicinal chemistry with ability to successfully andsimultaneously conduct medicinal chemistry on multiple projects is required
  • Demonstrated experience with automation,parallel synthesis and purification techniques
  • Solid understanding ofcellular/molecular biology, biochemistry, disease pharmacology, mechanisms ofdrug metabolism and molecular toxicology, pharmaco-kinetic and pharmaco-dynamicsciences, and formulations for the invivo evaluation of drug candidates is required
  • Thorough understanding of DNA-encodedlibrary technologies and protein target degradation strategies is preferred
  • Experience with computationalchemistry methods and biophysical techniques such as X-ray crystallography andmacromolecular NMR is preferred
  • Ability to integrate multiple R&Ddisciplines into a successful strategic project plan is required
  • Strong problem-solving skills fordeveloping creative, innovative solutions, and meeting project objectives are required
  • Demonstratedinfluence, negotiation, and conflict resolution skills, including the abilityto succeed within a matrix environment are required
  • Experience in managing projects,aligning actions with overall strategy, and supporting business cases fordecision-making is preferred
  • Strong track record of scientificcontributions including peer reviewed first-author publications, patentapplications, and presentations at major national meetings is required
  • Maintaining a lab presence andspending up to 30% of time in the lab is required
  • Up to 10% travel both domestically andinternationally is required
  • Johnson & Johnson is an Affirmative Action and EqualOpportunity Employer. All qualified applicants will receive consideration foremployment without regard to race, color, religion, sex, sexual orientation,gender identity, age, national origin, or protected veteran status and will notbe discriminated against on the basis of disability.




    Associated topics: chemical engineering, coatings, nutrition, pha, phenolic, plastics, polymer, polymer synthesis, polypropylene, polyurethane * The salary listed in the header is an estimate based on salary data for similar jobs in the same area. Salary or compensation data found in the job description is accurate.

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