Director, Innovation Biotherapeutic Discovery

Employment Type

: Full-Time


: Miscellaneous

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Pfizer Integrative Biotechnology Group (IBG) is within the Oncology division of Pfizer Worldwide Research & Development and is located in Pearl River, NY. IBG employs a multidisciplinary approach to target the tumor intrinsic mechanism of immune suppression and modulate the tumor microenvironment for the discovery and development of next generation oncology therapeutics and therapeutic combinations.

We seek to hire a Director to lead our innovative biotherapeutic discovery team focused on the discovery of tumor-associated antigens and development of biotherapeutics platforms to target solid tumors. The qualified candidate is a highly motivated, interactive, and creative individual who possesses substantial experience in cancer biotherapeutic discovery, protein engineering, antibody development and an interest in development biotherapeutics that combat and/or operate in the immune suppressive tumor microenvironment. The candidate will be an experienced program team leader with expertise in leveraging mouse hybridoma and phage-display antibody discovery platforms to identify monoclonal antibodies. S/he will also have experience in protein design and protein biophysical characterization. S/he will be an effective manager and mentor junior PhDs, associates and postdoctoral fellows. The candidate will be expected to effectively collaborate with colleagues in the Oncology Target Therapeutic Discovery group to identify and prioritize opportunities for biotherapeutic development.


  • Contribute to overall strategy of the innovative biotherapeutics discovery team by identifying opportunities to target immune suppression or develop biotherapeutics design to operate in the immune suppressive solid tumor microenvironment.
  • Lead a diverse team of protein engineers and molecular biologist in the discovery and design of novel biotherapeutics.
  • Lead team in the discovery of tumor targeted antibodies using both phage-display and mouse hybridoma discovery platforms.
  • Guide teams in the development, execution and interpretation of in vitro biophysical and functional cell-based screens to provide data-driven prioritization of biotherapeutic designs.
  • Guide teams in the design of in vivo studies to support proof-of-concept validation of targeted biotherapeutics.
  • Guide teams in design of studies to establish biological insights to both tumor intrinsic and immune cell responses to lead biotherapeutics.
  • Effectively manage projects and resources to maximize progress.
  • Provide engaging presentations to senior management and scientific advisors that highlights research progress and opportunities.
  • Work to build a positive external reputation by both publishing research in high-tier journals and presenting your team s work at international meetings.
  • Help to build a culture that embraces scientific excellence, continuous learning, and increasing our team s ability to deliver novel drug development opportunities through the rapid incorporation of emerging biotechnologies to ensure our team continues research on the leading-edge of cancer biology.

  • Ph.D. in biology, molecular biology or related discipline plus 7+ years of related experience as pharmaceutical industry investigator.
  • Experience in team management is essential
  • Advance knowledge of protein engineering and antibody development
  • Ability to design and supervise all aspects biotherapeutic discovery and development
  • Track record of publications and innovation
  • Ability to design and deliver novel solutions to challenging problems
  • Pro-active attitude and strong desire to discover novel biology and potential new drugs
  • Strong oral presentation and communication skills

  • An interest in conditionally activated biotherapeutics
  • An interest in mentorship of junior scientists and postdoctoral fellows.
  • Advanced knowledge of molecular biology with emphasis on high throughput protein expression, structure-guided rational protein design and the development of cell-based screens.
  • An understanding of both oncogenic signaling pathways and molecular mechanism that contribute to tumor immune evasion with an interest in identifying opportunities for biotherapeutics with broad activity in multiple tumor types.
  • An interest in tumor-immune cell interactions and mechanism that promote tumor immune surveillance.

  • Must have strong interpersonal and mentorship skills, and a desire to help develop team members to reach their full potential.

    There will be less than 10% travel.


  • Eligible for Relocation Package
  • Eligible for Employee Referral Bonus
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    EEO & Employment Eligibility

    Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

    N (Other) (United States of America)

    Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.

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