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Pfizer Integrative Biotechnology Group (IBG) is within the Oncology division of Pfizer Worldwide Research & Development and is located in Pearl River, NY. IBG employs a multidisciplinary approach to target the cancer cell cycle and modulate the tumor microenvironment for the discovery and development of next generation oncology therapeutics and therapeutic combinations. We are seeking a qualified candidate to join the group at a Senior Scientist level and contribute to drug discovery efforts leveraging functional genomics and advanced molecular biology strategies to elucidate drug mechanism of action and identifying drug combination opportunities. The ideal candidate for this position will be a highly collaborative and motivated scientist with an interest to design and execute Oncology target discovery projects using functional genomics screens. and advanced
molecular approaches. S/he will establish strong scientific rationale for cancer cell model selection, contribute to the design and development of function genomic libraries development, and establish molecular approaches for optimal in vitro and in vivo Functional Genomic screensbiological endpoint read-outs, and contribute to hit prioritization and the design and execution of drug target validation and mechanism of action studies focused on prioritized hits. S/he will lead target
validation studies to validate novel drug development opportunities and will work closely in a collaborative team environment. to contribute to establishing strategic focus and decision enabling data for drug
Design and execute CRISPR and/or RNAi functional genomic screens in vitro and in vivo for the discovery of novel development opportunities:
reporter systems to evaluate target biology.
opportunities through the rapid incorporation emerging biotechnologies to ensure our team continues research on the leading-edge of cancer biology
Perform work in a laboratory setting
NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
There will be less than 10% travel.
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EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.
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